Jian Guan

Senior Research Fellow
MD, University of Wuhan, China; PhD, University of Auckland

Contact details

Phone: +64 9 923 6134
Email: j.guan@auckland.ac.nz

Key research interests

• Nutritional developmental neuroscience
• Neuropharmacology

During the last 18 years, my research has been largely focused on understanding the biological function of insulin-like growth factors following brain injury and in chronic neurological conditions in neonatal, infant, young adult and aging brains. More recently I have been investigating the effects of nutrition on brain development, premature aging and cognitive function. I have extensive experience in designing animal based experiments and models, behavioral testing, neuronal anatomy, neurobiology and pharmacology. My research has resulted in 170 publications with high reference index (H-index 21), indicating the novelty of my research field.

Collaborations with:
Dr J-Y Wen, School of Pharmacy, The University of Auckland, on peptide formulation.
Dr J Perry, Liggins Institute, on the role of neuropeptides in angiogenesis.
Professor R Faull, Centre for Brain Research, The University of Auckland, on white matter degeneration in Huntington’s Disease.
Professor C Vorhees, Cincinnati Children’s Hospital, on developmental neuroscience.

1. 2009 Krishnamurthi, R V M., Kim A H., Mathai S. Rong Zhang Aand Guan J. Delayed treatment with a novel diketopiperazine improves motor function after 6-OHDA lesion in rats. J Brit Pharma 156, 662-672

2. 2008 Jacobson L, Zhang R, Elliffe D, Chen C, Mathai S, Mccarthy D, Waldvoge H And Guan J. Co-relation of cellular/vascular changes and spatial memory during aging in rats Exp Geront 43, 928-938

3. 2007 Guan J, Mathai S, Harris P, Brimble M, Wen Jy Zhang R Aand Gluckman P Peripheral administration of a novel diketopiperazine, NNZ 2591 prevents brain injury and improves somatosensory-motor function following hypoxia-ischemia in adult rats. Neuropharma 53: 749-762

4. 2004 Guan J, Thomas G B, Lin H, Matai S, Bachelor D C, George S, Fernandez J And Gluckman Pd Neuroprotective effects of the N-terminal tripeptide of insulin-like growth factor –1, glycine-proline-glutamate (GPE) following intravenous infusion in hypoxic-ischemic adult rats. Neuropharmacology Vol 47 (6): 892-903

5. 2003 Guan J, Bennet L Pd Gluckman Aand Gunn Aj, Insulin-like growth factor-1 and the ischemic brain. Progress in Neurology 70 (6), 443-462

Foundation for Research, Science and Technology Endogenous responses and novel human therapies.

“Research is an art and each publication is a beautiful piece of art work produced from knowledge and hard work with passion and belief.”