Developmental Programming in Mouse, Monkey, and Man: Where are we headed? Event as iCalendar

06 September 2017

12:30 - 1:30pm

Venue: Liggins Institute – Room 505-003

Location: 85 Park Road, Grafton, Auckland

Cost: Free

Contact email:

Prof Jed Friedman

Pregnancies complicated by maternal obesity and diabetes, or abnormal fetal growth and development affect up to 1 in 3 pregnant women and are associated with lifetime human suffering and enormous costs for society. Unfortunately, few effective treatments and intervention strategies are available, leaving these large patient groups with few options. Furthermore, emerging evidence clearly shows that adverse influences during fetal life, have a major impact on all organ systems, leading to metabolic, cardiopulmonary and neuropsychiatric disease later in life. There is an urgent need to identify early maternal and infant bioenergetic, epigenetic, inflammatory, and microbial biomarkers that mark mechanisms underlying metabolic disease in the next generation.  Mechanistic studies that utilize cutting-edge approaches including for example, the microbiome, epigenetics, stem cell biology, epidemiology, placental and fetal physiology are underway to discover the mechanistic links between early life environment and later health and disease. Likewise, clinical studies using meticulously characterized cohorts of pregnant women and infants and state-of-the art methodologies are being used in Colorado to identify critical associations between adverse influences and short- and long-term outcomes.

In this lecture we discuss how maternal and fetal/infant exposures can shift key pathways that may provide early clues for acceleration and mechanisms of disease as well as important opportunities for prevention and intervention using novel strategies to improve pregnancy outcomes and to prevent chronic diseases in future generations.

About the speaker: Dr. Jacob E. (Jed) Friedman received his PhD in Physiology, and following fellowships in Endocrinology, Biochemistry, and Molecular Genetics at Case Western Reserve University, joined the faculty at University of Colorado School of Medicine in 2000. He is Professor of Pediatrics (Neonatology), Biochemistry, Reproductive Sciences, and Director of the Colorado Program for Nutrition and Healthy Development, sponsored by the Colorado Children’s Hospital. Professor Friedman’s main focus is on “Developmental Origins of Health and Disease (DoHAD)”- particularly the mechanisms by which maternal health impacts Non-Alcoholic Fatty Liver Disease (NAFLD) in the next generation at the molecular, endocrine, and epigenetic levels.